A new look at cognitive functioning in pediatric MS

Authors: Lauren B Krupp, Emmanuelle Waubant, Michael Waltz, T Charles Casper, Anita Belman, Yolanda Wheeler, Jayne Ness, Jennifer Graves, Mark Gorman, Leslie Benson, Soe Mar, Manu Goyal, Teri Schreiner, Bianca Weinstock-Guttman, Moses Rodriguez, Jan-Mendelt Tillema, Timothy Lotze, Greg Aaen, Mary Rensel, John Rose, Tanuja Chitinis, Allan George, Leigh E Charvet, US Network of Pediatric MS Centers

Journal: Multiple Sclerosis: Clinical and Laboratory Research

Year Published: 2023

Objective: Cognitive involvement in pediatric multiple sclerosis (MS) relative to adult MS is less defined. This study advances our understanding by measuring cognitive performances in pediatric MS, adult MS, and pediatric healthy controls. Methods: Consecutive relapsing […]

Early neuropsychological markers of cognitive involvement in multiple sclerosis

Authors: Tehila Eilam-Stock, Michael T Shaw, Lauren B Krupp, Leigh E Charvet

Journal: Journal of Neurological Sciences

Year Published: 2021

Background Cognitive impairment due to multiple sclerosis (MS) is common and often limits occupational functioning, contributes to disability, and reduces quality of life. Early detection of cognitive involvement in MS is critical for treatment planning and […]

Brief Computer-Based Information Processing Measures are Linked to White Matter Integrity in Pediatric-Onset Multiple Sclerosis

Authors: Elizabeth Bartlett, Michael Shaw, Colleen Schwarz, Charles Feinberg, Christine DeLorenzo, Lauren B. Krupp, Leigh E. Charvet

Journal: Journal of Neuroimaging

Year Published: 2019

Background and Purpose: Pediatric-onset multiple sclerosis (POMS) is a demyelinating disorder with unique clinical challenges. A brief computer-administered cognitive screening battery measuring processing speed (Cogstate) and the Brief International Cognitive Assessment in MS (BICAMS) detect cognitive […]

Cognitive impairment in pediatric-onset multiple sclerosis is detected by the Brief International Cognitive Assessment for Multiple Sclerosis and computerized cognitive testing

Authors: Leigh E Charvet, Michael Shaw, Ariana Frontario, Dawn Langdon, Lauren B Krupp

Journal: Multiple Sclerosis: Clinical and Laboratory Research

Year Published: 2017

Background: Cognitive impairment is a common and troubling feature of pediatric-onset multiple sclerosis (POMS). Brief cognitive assessment in the outpatient setting can identify and longitudinally monitor cognitive involvement so that early intervention is possible. Objectives: The […]

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