Publications

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The feasibility, reliability and concurrent validity of the MSReactor computerized cognitive screening tool in multiple sclerosis.

Authors: Butzkueven H, Darby D, Kalincik T, Merlo D, Van der Walt A

Journal: Therapeutic advances in neurological disorders

DOI: 10.1177/1756286419859183

Year Published: 2019

Background: Multiple sclerosis (MS) cognitive tests are resource intensive and limited by practice effects that prevent frequent retesting. Brief, reliable and valid monitoring tools are urgently needed to detect subtle, subclinical cognitive changes in people with MS. Cognitive monitoring over time could contribute to a new definition of disease progression, supplementing routine clinical monitoring. Methods: […]

Explaining Upper or Lower Extremity Crossover Effects of Visuomotor Choice Reaction Time Training.

Authors: Banzer W, Engeroff T, Gerten S, Giesche F, Niederer D, Vogt L, Wilke J

Journal: Perceptual and motor skills

DOI: 10.1177/0031512519841755

Year Published: 2019

Current evidence indicates a strong relation between improved visuomotor choice reaction time (VMRT) and a reduced risk of lower extremity injury, making both lower- and upper extremity VMRT training paradigms valuable to athletes. This investigation studied as yet unconfirmed crossover effects of upper extremity training on lower extremity performance; and we evaluated underlying relevant perceptual […]

Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry.

Authors: Bickford D, Comacho M, Finley S, Flenniken D, Harel B, Insel PS, Mackin RS, Maruff P, Nosheny R, Truran D, Ulbright A, Weiner MW

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.dadm.2018.05.005

Year Published: 2018

Introduction: The purpose of this study is to compare online neuropsychological test performance of older adults across self-reported diagnoses of being cognitively normal, mild cognitive impairment, and dementia due to Alzheimer’s disease and to determine the association of memory concerns and family history of dementia on cognitive performance. Methods: Participants completed the Cogstate Brief Battery […]

Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner.

Authors: Ames D, Burnham S, Fernando WMADB, Gardener SL, Harrington K, Lim YY, Macaulay SL, Martins RN, Maruff P, Masters CL, Rainey-Smith SR, Rowe CC, Sohrabi HR, Taddei K, Verdile G, Weinborn M

Journal: Journal of Alzheimer's Disease

DOI: 10.3233/JAD-161158

Year Published: 2017

Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer’s disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of the apolipoprotein E (APOE) ɛ4 allele. We assessed the […]

Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months.

Authors: Ames D, Ellis KA, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Rainey-Smith SR, Rowe CC, Thai C, Villemagne VL

Journal: PloS One

DOI: 10.1371/journal.pone.0139082

Year Published: 2015

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. However, the relationship between these two biomarkers and cognitive decline is unclear. The aim of this study was to investigate the relationship between cerebral Aβ level, APOE […]

CogSport: reliability and correlation with conventional cognitive tests used in postconcussion medical evaluations.

Authors: Collie A, Darby D, Makdissi M, Maruff P, Mccrory P, McStephen M

Journal: Clinical Journal of Sport Medicine

Year Published: 2003

OBJECTIVE: To determine the repeatability of a computerized cognitive test designed to monitor recovery from concussion and assist team physicians make return to play decisions (CogSport). To determine the correlation between CogSport and two conventional neuropsychological tests. DESIGN: Prospective, serial investigation of cognitive function. SETTING: Professional and semi-professional Australian Football clubs and a university affiliated […]

Cognitive function in growth hormone deficiency and growth hormone replacement.

Authors: Falleti M, Maruff P

Journal: Hormone Research

DOI: 10.1159/000089325

Year Published: 2005

There is converging evidence from neuropsychological studies that growth hormone (GH) is associated with cognitive function. The aim of the current study was to review the existing neuropsychological literature for studies in which cognitive assessment had been conducted in patients with GH deficiency (GHD), and where change in cognitive function had been assessed following treatment […]

Cognitive deterioration associated with an expedition in an extreme desert environment.

Authors: Collie A, Darby D, Maruff P, McStephen M, Snyder P

Journal: British Journal of Sports Medicine

DOI: 10.1136/bjsm.2004.016204

Year Published: 2006

BACKGROUND: Prolonged exposure to extreme environments may result in cognitive changes that may influence decision making ability and increasing risk of injury or death. OBJECTIVE: To measure the cognitive performance of a healthy man as he completed a 17 day desert expedition. METHOD: A computer based cognitive test battery, subjective cognitive rating scale, and measures […]

A pilot study of the neuropsychological benefits of computerized cognitive rehabilitation in Ugandan children with HIV.

Authors: Bangirana P, Boivin MJ, Busman RA, Giordani B, Opoka RO, Page CF, Parikh SM

Journal: Neuropsychology

DOI: 10.1037/a0019312

Year Published: 2010

OBJECTIVE: Because antiretroviral treatment (ART) fails to improve neurocognitive impairment in children with HIV, we completed a pilot study evaluating the feasibility and cognitive benefit of computerized cognitive rehabilitation therapy (CCRT) in Ugandan children with HIV. METHOD: Sixty Ugandan children with HIV (23 on ART) were randomly assigned to 10 sessions of Captain’s Log CCRT […]

Impaired processing speed and attention in first-episode drug naive schizophrenia with deficit syndrome.

Authors: Chen C, Du J, Gao C, Hashimoto K, Jiang H, Jiang W, Li Y, Ma X, Wu J, Zhao M., Zhong N

Journal: Schizophrenia Research

DOI: 10.1016/j.schres.2014.09.005

Year Published: 2014

Although first-episode drug naive patients with schizophrenia are known to show cognitive impairment, the cognitive performances of these patients, who suffer deficit syndrome, compared with those who suffer non-deficit syndrome is undetermined. The aim of this study was to compare cognitive performances in first-episode drug-naive schizophrenia with deficit syndrome or non-deficit syndrome. First-episode drug naive […]

Heart rate variability and cognitive function: Effects of physical effort.

Authors: Darby D, Luft CD, Takase E

Journal: Biological Psychology

DOI: 10.1016/j.biopsycho.2009.07.007

Year Published: 2009

This study investigated alterations in heart rate variability (HRV) and cognitive performance before and after physical effort, for 30 high-level track and field athletes (23 males and 7 females). Interbeat intervals were assessed at the baseline and during each task of a CogState cognitive battery (simple reaction time, choice reaction time, working memory, short-term memory […]

Cutting a long story short: reaction times in acute stroke are associated with longer term cognitive outcomes.

Authors: Bernhardt J, Brodtmann A, Cumming TB, Darby D

Journal: Journal of the Neurological Sciences

DOI: 10.1016/j.jns.2012.07.004

Year Published: 2012

BACKGROUND: The viability and usefulness of cognitive assessment in acute stroke have been questioned, with practical challenges arising from the focal nature of neurological deficits as well as heterogeneity in arousal state. We aimed to test whether acute measures of attention correlate with attentional function at 3 months post-stroke. METHODS: Patients with confirmed stroke completed […]

Can working memory predict target-to-target interval effects in the P300?

Authors: Barry RJ, Gonsalvez CJ, Steiner GZ

Journal: International Journal of Psychophysiology

DOI: 10.1016/j.ijpsycho.2013.07.011

Year Published: 2013

It has been suggested that the P300 component of the ERP is an electrophysiological index of memory-updating processes associated with task-relevant stimuli. Component magnitude varies with the time separating target stimuli (target-to-target interval: TTI), with longer TTIs eliciting larger P300 amplitudes. According to the template-update perspective, TTI effects observable in the P300 reflect the updating […]

A randomized, double-blind, placebo-controlled, 16-week study of the H3 receptor antagonist, GSK239512 as a monotherapy in subjects with mild-to-moderate Alzheimer’s disease.

Authors: Beresford I, Berges AC, Boardley RL, Grove RA, Harrington CM, Horrigan JP, Lowy MT, Mahler A, Maruff P, Nathan PJ, Nicholls AP

Journal: Current Alzheimer Research

Year Published: 2014

INTRODUCTION: Histaminergic H3 receptors may play a role in modulating cholinergic and monoaminergic neurotransmission. This Phase II study evaluated the efficacy and safety of GSK239512, a highly potent, brain penetrant H3 receptor antagonist as monotherapy treatment for subjects with mild-to-moderate probable Alzheimer’s disease (AD). METHODS: In this 16-week, double-blind, randomized, parallel group study, 196 currently […]

Use of an experimental language acquisition paradigm for standardized neuropsychological assessment of learning: A pilot study in young and older adults.

Authors: Baker JE, Bruns L Jr, Hassenstab J, Lim YY, Maruff P, Masters CL

Journal: Journal of Clinical and Experimental Neuropsychology

DOI: 10.1080/13803395.2019.1665626

Year Published: 2020

Introduction: Despite the numerous episodic memory tasks used in neuropsychological assessment, relatively few learning tasks are available, with methods lacking the complexity and sophistication to capture very subtle changes in information acquisition. Method: We adapted a previously validated associative learning task for use within an online framework, utilizing real-world stimuli, in which learning of audio-visual […]

Hippocampal segmentation for brains with extensive atrophy using three-dimensional convolutional neural networks.

Authors: Adamo S, Akhavein H, Black SE, Gao F, Goubran M, Holmes M, MacIntosh B, Martel A, Masellis M, Nestor S, Ntiri EE, Ozzoude M, Ramirez J, Scott C, Swardfager W, Swartz R

Journal: Human brain mapping

DOI: 10.1002/hbm.24811

Year Published: 2020

Hippocampal volumetry is a critical biomarker of aging and dementia, and it is widely used as a predictor of cognitive performance; however, automated hippocampal segmentation methods are limited because the algorithms are (a) not publicly available, (b) subject to error with significant brain atrophy, cerebrovascular disease and lesions, and/or (c) computationally expensive or require parameter […]

Identification of Pre-Clinical Alzheimer’s Disease in a Population of Elderly Cognitively Normal Participants.

Authors: Doecke JD, Maruff P, Mengersen K, Rousseau J, van Havre Z, Villemagne VL, White N

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191095

Year Published: 2020

Alzheimer’s disease (AD) has a long pathological process, with an approximate lead-time of 20 years. During the early stages of the disease process, little evidence of the building pathology is identifiable without cerebrospinal fluid and/or imaging analyses. Clinical manifestations of AD do not present until irreversible pathological changes have occurred. Given an opportunity to provide […]

The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function?

Authors: Busby P, Harris D, Launer S, Lemke U, Maruff P, Sarant J, Schembri A

Journal: Journal of clinical medicine

DOI: 10.3390/jcm9010254

Year Published: 2020

Hearing loss is a modifiable risk factor for dementia in older adults. Whether hearing aid use can delay the onset of cognitive decline is unknown. Participants in this study (aged 62-82 years) were assessed before and 18 months after hearing aid fitting on hearing, cognitive function, speech perception, quality of life, physical activity, loneliness, isolation, […]

Associations of Apolipoprotein E ε4 Genotype and Ball Heading With Verbal Memory in Amateur Soccer Players.

Authors: Davies P, Freudenberg-Hua Y, Hu S, Hunter LE, Kim M, Lipton ML, Lipton RB, Srinivasan P, Stewart WF

Journal: JAMA Neurology

DOI: 10.1001/jamaneurol.2019.4828

Year Published: 2020

Importance: Emerging evidence suggests that long-term exposure to ball heading in soccer, the most popular sport in the world, confers risk for adverse cognitive outcomes. However, the extent to which the apolipoprotein E ε4 (APOE ε4) allele, a common risk factor for neurodegeneration, and ball heading are associated with cognition in soccer players remains unknown. […]

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Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance.

Authors: Ames D, Dang C, Doecke JD, Fripp J, Harrington KD, Hickey M, Laws SM, Lim YY, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Snyder PJ, Sohrabi HR, Villemagne VL, Weinborn M, Xia Y, Yassi N

Journal: Alzheimer's & dementia : diagnosis assessment & disease monitoring

DOI: 10.1016/j.dadm.2019.05.005

Year Published: 2019

Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older […]

SuperAging: Current findings yield future challenges-A response to Rogalski and Goldberg.

Authors: Dang C, Maruff P

Journal: Alzheimer's & dementia : diagnosis assessment & disease monitoring

DOI: 10.1016/j.dadm.2019.05.004

Year Published: 2019

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Influence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer’s Disease.

Authors: Ames D, Chen C, Desmond PM, Fowler C, Hilal S, Kuijf H, Lim YY, Martins R, Maruff P, Masters CL, Rowe C, Salvado O, Villemagne V, Watson R, Xia Y, Yassi N, Yates P

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191028

Year Published: 2019

BACKGROUND: Quantifying the contribution of cerebrovascular disease to the clinical and pathological profile of Alzheimer’s disease is challenging. OBJECTIVE: We aimed to determine the influence of cerebrovascular disease, amyloid-β (Aβ), and their comorbidity on cognitive decline, hippocampal atrophy, and Aβ deposition, by evaluating data from the Australian Imaging, Biomarker and Lifestyle Study of Ageing. METHODS: […]

Identification of Pre-Clinical Alzheimer’s Disease in a Population of Elderly Cognitively Normal Participants.

Authors: Doecke JD, Maruff P, Mengersen K, Rousseau J, van Havre Z, Villemagne V, White N

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191095

Year Published: 2019

Alzheimer’s disease (AD) has a long pathological process, with an approximate lead-time of 20 years. During the early stages of the disease process, little evidence of the building pathology is identifiable without cerebrospinal fluid and/or imaging analyses. Clinical manifestations of AD do not present until irreversible pathological changes have occurred. Given an opportunity to provide […]

C-reactive protein and response to lurasidone treatment in children and adolescents with bipolar I depression: Results from a placebo-controlled trial.

Authors: Loebel A, Pikalov A, Raison CL, Siu C, Tocco M

Journal: Brain behavior and immunity

DOI: 10.1016/j.bbi.2019.12.010

Year Published: 2019

This study sought to investigate associations between levels of high-sensitivity c-reactive protein (hsCRP) prior to treatment and change in depressive symptoms and cognition in a short-term, double-blind, placebo-controlled study of lurasidone in children and adolescents with bipolar I depression. Patients 10-17 years of age with a DSM-5 diagnosis of bipolar I depression were randomized to […]

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Neuropsychological Trajectories Associated with Adolescent Alcohol and Cannabis Use: A Prospective 14-Year Study.

Authors: Coronado C, Courtney KE, Infante MA, Jacobus J, Nguyen-Louie TT, Worley M

Journal: Journal of the International Neuropsychological Society : JINS

DOI: 10.1017/S1355617719001395

Year Published: 2019

OBJECTIVES: Alcohol and cannabis remain the substances most widely used by adolescents. Better understanding of the dynamic relationship between trajectories of substance use in relation to neuropsychological functioning is needed. The aim of this study was to examine the different impacts of within- and between-person changes in alcohol and cannabis use on neuropsychological functioning over […]

Effects of transcranial direct current stimulation on cognition and symptoms in Chinese patients with schizophrenia✰.

Authors: Davis JM, Faull R, Jiang J, Jin H, Li C, Md WL, Smith RC, Szabo V, Wang J, Wang Y

Journal: Psychiatry Research

DOI: 10.1016/j.psychres.2019.112617

Year Published: 2019

There is preliminary evidence that transcranial direct current stimulation(tDCS) may improve symptoms and cognitive function in schizophrenia, but the generalizability of these results needs further investigation. We present a study of the effects of active vs. sham tDCS on cognition and symptoms in a sample of 45 Chinese patients with schizophrenia who showed significant cognitive […]

Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD.

Authors: Amariglio RE, Buckley R, Johnson KA, Maruff P, Masters CL, Mormino E, Papp KV, Rentz DM, Sperling RA, Villemagne VL

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2019.09.074

Year Published: 2019

INTRODUCTION: Demonstrating the “clinical meaningfulness” of slowing early cognitive decline in clinically normal (CN) older adults with elevated amyloid-β (Aβ+) is critical for Alzheimer’s disease secondary prevention trials and for understanding early cognitive progression. METHODS: Cox regression analyses were used to determine whether 3-year slopes on the preclinical Alzheimer’s cognitive composite predicted MCI diagnosis and […]

Computerized cognitive performance assessments in the Brooklyn Cognitive Impairments in Health Disparities Pilot Study.

Authors: Adler K, Apple S, Cheng F, Cohen C, Friedlander A, Gustafson D, Levine SR, Lucchesi M, Maruff P, Reinhardt M, Salmieri M, Stevens D, Weingast S

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2019.07.004

Year Published: 2019

INTRODUCTION: Detecting cognitive impairment in diverse, health disparities communities is an urgent health care priority. METHODS: The Brooklyn Cognitive Impairments in Health Disparities Pilot Study investigated quantitative aspects and liking of a computerized cognitive performance assessment, Cognigram, among individuals ≥ 40 years in traditional and nontraditional primary care settings. RESULTS: Cognigram was piloted in the […]

Health-related quality of life, emotional burden, and neurocognitive function in the first generation of metastatic melanoma survivors treated with pembrolizumab: a longitudinal pilot study.

Authors: Awada G, De Cremer J, De Ridder M, Leys C, Neyns B, Rogiers A, Schembri A, Theuns P

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

DOI: 10.1007/s00520-019-05168-3

Year Published: 2019

PURPOSE: The aim of this study was to assess the evolution of health-related quality of Life (HRQoL), emotional burden, and neurocognitive function in the first-generation metastatic melanoma survivors treated with pembrolizumab. METHODS: Survivors were defined as patients who achieved a durable remission for at least 6 months after initiating pembrolizumab in a single-center observational study […]