attention

An evaluation of computerized attention and executive function measures for use with school age children with neurofibromatosis type 1

Authors: Sara K Pardej, Christina L Casnar, Brianna D Yund, Bonita P Klein-Tasman

Journal: Child Neuropsychology

Year Published: 2024

The present study investigated the performance of children with neurofibromatosis type 1 on computerized assessments of attention and executive function. Relations to ADHD symptomatology were also examined. Participants included 37 children (20 male) with NF1 (9-13 […]

A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M 1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer’s disease

Authors: Pradeep J Nathan, S Babli Millais, Alex Godwood, Odile Dewit, David M Cross, Janet Liptrot, Bharat Ruparelia, Stephen Paul Jones, Geor Bakker, Paul T Maruff, Gregory A Light, Alastair J H Brown, Malcolm Peter Weir, Miles Congreve, Tim Tasker

Journal: Alzheimer's & Dementia

Year Published: 2022

Introduction: This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild-to-moderate Alzheimer’s disease (AD) on background donepezil 10 mg/day. Methods: A randomized, double-blind, placebo-controlled 4-week […]

A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M 1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer’s disease

Authors: Pradeep J Nathan, S Babli Millais, Alex Godwood, Odile Dewit, David M Cross, Janet Liptrot, Bharat Ruparelia, Stephen Paul Jones, Geor Bakker, Paul T Maruff, Gregory A Light, Alastair J H Brown, Malcolm Peter Weir, Miles Congreve, Tim Tasker

Journal: Alzheimer's & Dementia : Translational Research & Clinical Interventions

Year Published: 2022

Introduction: This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild-to-moderate Alzheimer’s disease (AD) on background donepezil 10 mg/day. Methods: A randomized, double-blind, placebo-controlled 4-week […]

The Relationship Between Central Auditory Tests and Neurocognitive Domains in Adults Living With HIV

Authors: Christopher E Niemczak, Jonathan D Lichtenstein, Albert Magohe, Jennifer T Amato, Abigail M Fellows, Jiang Gui, Michael Huang, Catherine C Rieke, Enica R Massawe, Michael J Boivin, Ndeserua Moshi, Jay C Buckey

Journal: Frontiers in Neuroscience

Year Published: 2021

Objective: Tests requiring central auditory processing, such as speech perception-in-noise, are simple, time efficient, and correlate with cognitive processing. These tests may be useful for tracking brain function. Doing this effectively requires information on which tests […]

Changes in functional connectivity in people with HIV switching antiretroviral therapy

Authors: Sofia Toniolo, Mara Cercignani, Borja Mora-Peris, Jonathan Underwood, Jasmini Alagaratnam, Marco Bozzali, Marta Boffito, Mark Nelson, Alan Winston, Jaime H Vera

Journal: Journal of Neuro Virology

Year Published: 2020

We assessed changes in functional connectivity by fMRI (functional magnetic resonance imaging) and cognitive measures in otherwise neurologically asymptomatic people with HIV (PWH) switching combination antiretroviral therapy (cART). In a prospective study (baseline and follow-up after […]

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