Apolipoprotein E

Effect of APOE Genotype on Amyloid Deposition, Brain Volume, and Memory in Cognitively Normal Older Individuals.

Authors: Bourgeat P, Fowler C, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL, Williamson R

Journal: Journal of Alzheimer's Disease

BACKGROUND: The association between the apolipoprotein E (APOE) ɛ4 allele and high risk of developing Alzheimer’s disease (AD) dementia before the age of 80 has been recognized for over 30 years. However, the timing and mode […]

Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner.

Authors: Ames D, Burnham S, Fernando WMADB, Gardener SL, Harrington K, Lim YY, Macaulay SL, Martins RN, Maruff P, Masters CL, Rainey-Smith SR, Rowe CC, Sohrabi HR, Taddei K, Verdile G, Weinborn M

Journal: Journal of Alzheimer's Disease

Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer’s disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at […]

APOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer’s disease

Authors: Ames D, Ellis KA, Harrington K, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rowe CC, Snyder PJ, Villemagne VL

Journal: Neurobiology of Aging

The apolipoprotein E (APOE) ɛ4 allele and high levels of beta-amyloid (Aβ) are associated with episodic memory decline and risk for Alzheimer’s disease. However, there is debate about independent or interactive effects of ɛ4 on Aβ-related […]

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