Brain health registry GenePool study: A novel approach to online genetics research
Introduction Remote data collection, including the establishment of online registries, is a novel approach to efficiently identify risk for cognitive decline and Alzheimer’s disease (AD) in older adults, with growing evidence for feasibility and validity. Addition […]
Visual Memory Deficits in Middle-Aged APOEɛ4 Homozygotes Detected Using Unsupervised Cognitive Assessments
Background: The apolipoprotein E (APOE) ɛ4 allele is associated with dose-response effects on cognitive dysfunction and dementia risk in older adults. However, its effects on cognition in middle-aged adults remains unclear. Objective: We examined effects of […]
APOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer’s disease
The apolipoprotein E (APOE) ɛ4 allele and high levels of beta-amyloid (Aβ) are associated with episodic memory decline and risk for Alzheimer’s disease. However, there is debate about independent or interactive effects of ɛ4 on Aβ-related […]
