Duration of preclinical, prodromal, and dementia stages of Alzheimer’s disease in relation to age, sex, and APOE genotype.

Authors: Blennow K, Bos I, Freund-Levi Y, Handels R, Kern S, Maruff P, Muniz-Terrera G, Olde Rikkert M, Ousset PJ, Scheltens P, Sikkes SAM, Skoog I, Soininen H, Spiru L, Tsolaki M, van den Hout A, van der Flier WM, Verhey FRJ, Vermunt L, Visser PJ, Wallin ÅK, Zetterberg H

Journal: Alzheimer's & Dementia

INTRODUCTION: We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer’s disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration. METHODS: We […]

Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer’s disease: Findings from three well-characterized cohorts.

Authors: Amariglio RE, Buckley RF, Burnham S, Chhatwal J, Dobson A, Donohue MC, Dore V, Hanseeuw BJ, Hedden T, Jacobs HIL, Johnson KA, Kirn D, Lim YY, Maruff P, Masters CL, Mormino EC, Papp KV, Properzi MJ, Rabin JS, Rentz DM, Rowe CC, Schultz AP, Sperling RA, Villemagne VL, Waller M

Journal: Alzheimer's and Dementia

INTRODUCTION: Our objective was to investigate the effect of sex on cognitive decline within the context of amyloid β (Aβ) burden and apolipoprotein E genotype. METHODS: We analyzed sex-specific effects on Aβ-positron emission tomography, apolipoprotein, and […]

β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men.

Authors: Ames D, Dore V, Esterlis I, Holmes SE, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Mazure CM, Pietrzak RH, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL

Journal: The American Journal of Geriatric Psychiatry

OBJECTIVE: To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. METHODS: Cross-sectional data were analyzed from 423 older adults from the […]

Aβ-related memory decline in APOE ε4 noncarriers: Implications for Alzheimer disease.

Authors: Ames D, Bourgeat P, Fowler C, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Porter T, Rainey-Smith S, Rowe CC, Salvado O, Snyder PJ, Villemagne VL

Journal: Neurology

OBJECTIVE: As the absence of Aβ-related memory decline in APOE ε4 noncarriers may be due to the relative brevity of previous studies, we aimed to characterize Aβ-related cognitive decline over 72 months in APOE ε4 carriers […]

Influence of amyloid and apolipoprotein E on cognitive performance in a late middle-aged cohort.

Authors: Christianson TJ, Hagen CE, Jack CR Jr, Knopman DS, Kremers WK, Lowe VJ, Machulda MM, Mielke MM, Petersen RC, Roberts RO, Vemuri P

Journal: Alzheimer's & Dementia

INTRODUCTION: Few studies have examined the effects of amyloid and apolipoprotein E (APOE) genotype on cognition among middle-aged individuals. METHODS: We included 464 cognitively normal, test-naïve, participants with Pittsburgh compound B positron emission tomography amyloid imaging, […]

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