amyloid

Diagnostic and Prognostic Accuracy of the Cogstate Brief Battery and Auditory Verbal Learning Test in Preclinical Alzheimer’s Disease and Incident Mild Cognitive Impairment: Implications for Defining Subtle Objective Cognitive Impairment

Authors: Nikki H Stricker, Emily S Lundt, Sabrina M Albertson, Mary M Machulda, Shehroo B Pudumjee, Walter K Kremers, Clifford R Jack, David S Knopman, Ronald C Petersen, Michelle M Mielke

Journal: Journal of Alzheimer's Disease

Year Published: 2020

Background: There are detectable cognitive differences in cognitively unimpaired (CU) individuals with preclinical Alzheimer’s disease (AD). Objective: To determine whether cross-sectional performance on the Cogstate Brief Battery (CBB) and Auditory Verbal Learning Test (AVLT) could identify […]

Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer’s Disease.

Authors: Asthana S, Berman SE, Bilgel M, Blennow K, Carlsson CM, Christian BT, Clark LR, Jedynak B, Johnson SC, Koscik RL, Mueller KD, Nicholas CR, Norton D, Racine AM, Zetterberg H

Journal: Journal of Alzheimer's Disease

Year Published: 2016

It is not known whether computerized cognitive assessments, like the CogState battery, are sensitive to preclinical cognitive changes or pathology in people at risk for Alzheimer’s disease(AD). In 469 late middle-aged participants from the Wisconsin Registry […]

Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia.

Authors: Ames D, Bourgeat P, Fowler C, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rainey-Smith S, Rowe CC, Salvado O, Snyder PJ, Villemagne VL

Journal: Journal of Molecular Neuroscience

Year Published: 2016

In a group of older adults with very mild dementia, we aimed to characterize the nature and magnitude of cognitive decline as measured by the Cogstate Brief Battery, in relation to Aβ levels and hippocampal volume. […]

Influence of amyloid and apolipoprotein E on cognitive performance in a late middle-aged cohort.

Authors: Christianson TJ, Hagen CE, Jack CR Jr, Knopman DS, Kremers WK, Lowe VJ, Machulda MM, Mielke MM, Petersen RC, Roberts RO, Vemuri P

Journal: Alzheimer's & Dementia

Year Published: 2015

INTRODUCTION: Few studies have examined the effects of amyloid and apolipoprotein E (APOE) genotype on cognition among middle-aged individuals. METHODS: We included 464 cognitively normal, test-naïve, participants with Pittsburgh compound B positron emission tomography amyloid imaging, […]

Amyloid-β Related Memory Decline is not Associated with Subjective or Informant Rated Cognitive Impairment in Healthy Adults.

Authors: Ames D, Buckley R, Ellis KA, Harrington K, Hollands S, Lautenschlager N, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rowe CC, Snyder PJ, Villemagne VL

Journal: Journal of Alzheimer's Disease

Year Published: 2014

BACKGROUND: The detection of early Alzheimer’s disease (AD) can rely on subjective and informant reports of cognitive impairment. However, relationships between subjective cognitive impairment, objectively measured cognitive function, and amyloid-β (Aβ) biomarkers remain unclear. Objective: To […]

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