alzheimer’s disease

An Online, Person-Centered, Risk Factor Management Program to Prevent Cognitive Decline: Protocol for A Prospective Behavior-Modification Blinded Endpoint Randomized Controlled Trial

Authors: Yen Ying Lim, Darshini Ayton, Stephanie Perin, Alexandra Lavale, Nawaf Yassi, Rachel Buckley, Christopher Barton, Loren Bruns, Renata Morello, Stephanie Pirotta, Emily Rosenich, Shantha M W Rajaratnam, Richard Sinnott, Amy Brodtmann, Ashley I Bush, Paul Maruff, Leonid Churilov, Anna Barker, Matthew P Pase , BetterBrains Research Group

Journal: Journal of Alzheimer's Disease

Year Published: 2021

Background Several modifiable risk factors for dementia have been identified, although the extent to which their modification leads to improved cognitive outcomes remains unclear. Objective The primary aim is to test the hypothesis that a behavior […]

Pilot Evaluation of the Unsupervised, At-Home Cogstate Brief Battery in ADNI-2

Authors: Chris J Edgar, Eric Siemers, Paul Maruff, Ronald C Petersen, Paul S Aisen, Michael W Weiner, Bruce Albala, Alzheimer’s Disease Neuroimaging Initiative

Journal: Journal of Alzheimer's Disease

Year Published: 2021

Background There is a need for feasible, scalable assessments to detect cognitive impairment and decline. The Cogstate Brief Battery (CBB) is validated for Alzheimer’s disease (AD) and in unsupervised and bring your own device contexts. The […]

Sleep symptomatology is associated with greater subjective cognitive concerns: Findings from the community-based Healthy Brain Project

Authors: Jessica Nicolazzo, Katharine Xu, Alexandra Lavale, Rachel Buckley, Nawaf Yassi, Garun S Hamilton, Paul Maruff, Andree-Ann Baril, Yen Ying Lim, Matthew P Pase

Journal: Sleep

Year Published: 2021

Study objectives To examine if sleep symptomatology was associated with subjective cognitive concerns or objective cognitive performance in a dementia-free community-based sample. Methods A total of 1421 middle-aged participants (mean±standard deviation = 57±7; 77% female) from […]

Visual Memory Deficits in Middle-Aged APOEɛ4 Homozygotes Detected Using Unsupervised Cognitive Assessments

Authors: Yen Ying Lim, Matthew P Pase, Rachel F Buckley, Nawaf Yassi, Lisa Bransby, Christopher Fowler, Simon M Laws, Colin L Masters, Paul Maruff

Journal: Journal of Alzheimer's Disease

Year Published: 2021

Background: The apolipoprotein E (APOE) ɛ4 allele is associated with dose-response effects on cognitive dysfunction and dementia risk in older adults. However, its effects on cognition in middle-aged adults remains unclear. Objective: We examined effects of […]

The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer’s Disease (TRC-PAD): Experience from the First 3 Years

Authors: S Walter, O G Langford, T B Clanton, G A Jimenez-Maggiora, R Raman, M S Rafii, E J Shaffer, R A Sperling, J L Cummings, P S Aisen

Journal: The Journal of Prevention of Alzheimer's Disease

Year Published: 2020

Background: The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer’s disease (TRC-PAD) aims to accelerate enrollment for Alzheimer’s disease (AD) clinical trials by remotely identifying and tracking individuals who are at high risk for developing symptoms of […]

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