Exploring the repurposing potential of β2-adrenergic receptor agonists for cognitive function: Evidence from the PharmLines Initiative Retrospective Cohort Study
Background: Preclinical studies suggest β2-adrenergic receptor agonists may exert neuroprotective effects, but evidence in human populations is limited. Objective: To examine the association between β2-adrenergic receptor agonist use and cognitive performance in older adults. Methods: This […]
Evaluating Physical Frailty as a Marker of Cognitive Health in Older Adults without Dementia
Physical frailty is associated with adverse health outcomes in older adults, including cognitive decline; however, the underlying biological and pathophysiological mechanisms linking frailty to neuropathological biomarkers remain underexplored, particularly in older adults without dementia. This study […]
Scalable Markers for Early Cognitive Decline: Plasma p-tau217, Subjective Cognitive Concerns, and Digital Testing: Results from the A4/LEARN studies
Background and objectives: Although amyloid positron emission tomography (PET) and Cerebrospinal fluid (CSF) biomarkers remain the standard for confirming Alzheimer’s disease (AD) pathology, their use is impractical for screening or routine prognostic assessment. Plasma phosphorylated tau […]
The proportion of plant-based food consumption during midlife and cognitive health in later life in Australian women: data from the Women’s Healthy Ageing Project (WHAP)
Purpose: Plant-based food (PBF) is well-known for its benefits for physical health; however, its impacts on brain health are less well understood, especially in ageing women. This study aimed to examine the association between different proportions […]
Relationship Between Endothelial Function, Vital Parameters, and Cognitive Performance in Community Dwellers with Subjective Cognitive Decline: An Observational Study with Six Months Follow Up
Background: With advancing age, cognitive decline is frequently associated with endothelial dysfunction, but data on vascular performance prior to the onset of mild cognitive impairment (MCI) is scarce. Objective: To investigate the relationship between endothelial function, […]
