alzheimer disease

Amyloid β-associated cognitive decline in the absence of clinical disease progression and systemic illness.

Authors: Ames D, Dore V, Harrington KD, Hassenstab J, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Rainey-Smith S, Robertson J, Rowe CC, Salvado O, Snyder PJ, Villemagne VL

Journal: Alzheimer's & Dementia

INTRODUCTION: High levels of amyloid β (Aβ) are associated with cognitive decline in cognitively normal (CN) older adults. This study investigated the nature of cognitive decline in healthy individuals who did not progress to mild cognitive […]

The Relationship between Sleep Quality and Brain Amyloid Burden.

Authors: Ames D, Brown BM, Bucks RS, Fowler C, Laws SM, Macaulay SL, Martins RN, Maruff P, Masters CL, Rainey-Smith SR, Rowe CC, Sohrabi HR, Taddei K, Villemagne VL, Weinborn M

Journal: Sleep

STUDY OBJECTIVES: To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E (APOE) ε4 allele on any associations found. METHODS: This study […]

Disclosure of positron emission tomography amyloid imaging results: A preliminary study of safety and tolerability.

Authors: Getter C, Lim YY, Maruff P, Snyder PJ

Journal: Alzheimer's & Dementia

INTRODUCTION: Three 18F-labeled radiopharmaceuticals have been Food and Drug Administration-approved for the identification of cortical amyloidosis in clinical settings. Although there has been strong debate among professionals as to the ethical and social consequences of disclosing […]

Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months.

Authors: Ames D, Ellis KA, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Rainey-Smith SR, Rowe CC, Thai C, Villemagne VL

Journal: PloS One

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. However, the relationship between these two biomarkers and […]

APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer’s disease.

Authors: Ames D, Ellis KA, Harrington K, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rembach A, Rowe CC, Snyder PJ, Villemagne VL

Journal: Molecular Psychiatry

Accumulation of β-amyloid (Aβ) in the brain is associated with memory decline in healthy individuals as a prelude to Alzheimer’s disease (AD). Genetic factors may moderate this decline. We examined the role of apolipoprotein E (ɛ4 […]

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