alzheimer disease

Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months.

Authors: Christine Thai, Yen Ying Lim, Victor L Villemagne, Simon M Laws, David Ames, Kathryn A Ellis, Stephanie R Rainey-Smith, Ralph N Martins, Colin L Masters, Christopher C Rowe, Paul Maruff, Australian Imaging, Biomarkers and Lifestyle (AIBL) Research Group

Journal: PloS One

Year Published: 2015

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. However, the relationship between these two biomarkers and […]

Intraindividual cognitive decline using a brief computerized cognitive screening test

Authors: David G Darby, Robert H Pietrzak, Julia Fredrickson, Michael Woodward, Lynette Moore, Amy Fredrickson, Jack Sach, Paul Maruff

Journal: Alzheimer's & Dementia

Year Published: 2012

Background: Progressive intraindividual decline in memory and cognition is characteristic of dementia and may be useful in detecting very early Alzheimer’s disease pathology. Methods: This study evaluated the slopes of cognitive performance over a 12-month period […]

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