AIBL

Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study.

Authors: Ames D, Dore V, Ellis K, Esterlis I, Fowler C, Holmes SE, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Mazure CM, Pietrzak RH, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL

Journal: International Journal of Geriatric Psychiatry

OBJECTIVE: Depressive and anxiety symptoms are common in older adults, significantly affect quality of life, and are risk factors for Alzheimer’s disease. We sought to identify the determinants of predominant trajectories of depressive and anxiety symptoms […]

Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-up.

Authors: Ames D, Baker D, Burnham SC, Bush AI, Doecke JD, Faux NG, Laws SM, Macaulay SL, Martins RN, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Savage G, Villemagne VL, Wilson W

Journal: Neurology

OBJECTIVE: We assessed a blood-based signature, which previously demonstrated high accuracy at stratifying individuals with high or low neocortical β-amyloid burden (NAB), to determine whether it could also identify individuals at risk of progression to Alzheimer […]

Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer’s disease pathophysiology (SNAP) or Alzheimer’s disease pathology: a longitudinal study.

Authors: Ames D, Bourgeat P, Brown B, Burnham SC, Dore V, Laws S, Martins RN, Maruff P, Masters CL, Rowe CC, Salvado O, Savage G, Villemagne VL

Journal: The Lancet. Neurology

BACKGROUND: Brain amyloid β (Aβ) deposition and neurodegeneration have been documented in about 50-60% of cognitively healthy elderly individuals (aged 60 years or older). The long-term cognitive consequences of the presence of Alzheimer’s disease pathology and […]

Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL).

Authors: Ames D, Bush AI, Darby D, Ellis KA, Graham PL, Lautenschlager NT, Macaulay SL, Martins RN, Maruff P, Masters CL, McBride SJ, Pike KE, Rainey-Smith SR, Rembach A, Robertson J, Rowe CC, Savage G, Szoeke C, Villemagne VL, Wilson W, Woodward M, Zhang P

Journal: International Psychogeriatrics

BACKGROUND: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing is a prospective study of 1,112 individuals (211 with Alzheimer’s disease (AD), 133 with mild cognitive impairment (MCI), and 768 healthy controls (HCs)). Here […]

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