Access hundreds of peer-reviewed cognitive research papers published by leading neuroscientists using Cogstate technology.



Baseline Amnestic Severity Predicts Progression From Amnestic Mild Cognitive Impairment to Alzheimer Disease Dementia at 3 Years.

Authors: Ames D, Bradfield NI, Burnham S, Darby D, Ellis KA, Lautenschlager NT, Martins RN, Maruff P, Masters CL, Rainey-Smith SR, Robertson J, Rowe C, Savage G, Woodward M

Journal: Alzheimer Disease and Associated Disorders

DOI: 10.1097/WAD.0000000000000252

Year Published: 2018

BACKGROUND: Given the long preclinical disease course of Alzheimer disease (AD) pathology, novel treatments may be more efficacious if administered before the emergence of dementia. Thus, accurate prediction of who will develop AD dementia is of key importance in selecting individuals for trials of treatment and may become crucial for future selection of patients for […]

Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden.

Authors: Ames D, Brown BM, Bucks RS, Laws SM, Martins RN, Maruff P, Masters CL, Mazzucchelli GN, Milicic L, Porter T, Rainey-Smith SR, Rowe CC, Salvado O, Sohrabi HR, Taddei K, Villemagne VL, Weinborn M

Journal: Translational Psychiatry

Volume & Issue: 8 & 1

Page No.: 47

DOI: 10.1038/s41398-018-0094-x

Year Published: 2018

The glymphatic system is postulated to be a mechanism of brain Aβ-amyloid clearance and to be most effective during sleep. Ablation of the astrocytic end-feet expressed water-channel protein, Aquaporin-4, in mice, results in impairment of this clearance mechanism and increased brain Aβ-amyloid deposition, suggesting that Aquaporin-4 plays a pivotal role in glymphatic function. Currently there […]

A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort.

Authors: Ames D, Bush AI, Doecke J, Gupta VB, Hone E, James I, Martins RN, Masters CL, O'Bryant S, Pedrini S, Rowe CC, Villemagne VL

Journal: Scientific Reports

Volume & Issue: 7 & 1

Page No.: 14057

DOI: 10.1038/s41598-017-14020-9

Year Published: 2017

Alzheimer’s Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this […]

Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study.

Authors: Ames D, Dore V, Ellis K, Esterlis I, Fowler C, Holmes SE, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Mazure CM, Pietrzak RH, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL

Journal: International Journal of Geriatric Psychiatry

DOI: 10.1002/gps.4761

Year Published: 2017

OBJECTIVE: Depressive and anxiety symptoms are common in older adults, significantly affect quality of life, and are risk factors for Alzheimer’s disease. We sought to identify the determinants of predominant trajectories of depressive and anxiety symptoms in cognitively normal older adults. METHOD: Four hundred twenty-three older adults recruited from the general community underwent Aβ positron […]

Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-up.

Authors: Ames D, Baker D, Burnham SC, Bush AI, Doecke JD, Faux NG, Laws SM, Macaulay SL, Martins RN, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Savage G, Villemagne VL, Wilson W

Journal: Neurology

Volume & Issue: 87 & 11

Page No.: 1093-101

DOI: 10.1212/WNL.0000000000003094

Year Published: 2016

OBJECTIVE: We assessed a blood-based signature, which previously demonstrated high accuracy at stratifying individuals with high or low neocortical β-amyloid burden (NAB), to determine whether it could also identify individuals at risk of progression to Alzheimer disease (AD) within 54 months. METHODS: We generated the blood-based signature for 585 healthy controls (HCs) and 74 participants […]

Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer’s disease pathophysiology (SNAP) or Alzheimer’s disease pathology: a longitudinal study.

Authors: Ames D, Bourgeat P, Brown B, Burnham SC, Dore V, Laws S, Martins RN, Maruff P, Masters CL, Rowe CC, Salvado O, Savage G, Villemagne VL

Journal: The Lancet. Neurology

Volume & Issue: 15 & 10

Page No.: 1044-53

DOI: 10.1016/S1474-4422(16)30125-9

Year Published: 2016

BACKGROUND: Brain amyloid β (Aβ) deposition and neurodegeneration have been documented in about 50-60% of cognitively healthy elderly individuals (aged 60 years or older). The long-term cognitive consequences of the presence of Alzheimer’s disease pathology and neurodegeneration, and whether they have an independent or synergistic effect on cognition, are unclear. We aimed to characterise the […]

Aβ amyloid, cognition, and APOE genotype in healthy older adults.

Authors: Ames D, Darby D, Ellis KA, Harrington K, Lim YY, Martins RN, Maruff P, Masters CL, Rowe C, Savage G, Szoeke C, Villemagne VL

Journal: Alzheimer's & Dementia

Volume & Issue: 9 & 5

Page No.: 538-45

DOI: 10.1016/j.jalz.2012.07.004

Year Published: 2013

BACKGROUND: Only one study has investigated the relationship between cerebral β-amyloid (Aβ), apolipoprotein E (APOE) ε4 genotype, and cognition. Although significant relationships between cerebral Aβ and cognition were observed in ε4 carriers but not noncarriers, the magnitude of this relationship was not reported. Further, when demographic variables were controlled, the influence of APOE ε4 on […]

Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL).

Authors: Ames D, Bush AI, Darby D, Ellis KA, Graham PL, Lautenschlager NT, Macaulay SL, Martins RN, Maruff P, Masters CL, McBride SJ, Pike KE, Rainey-Smith SR, Rembach A, Robertson J, Rowe CC, Savage G, Szoeke C, Villemagne VL, Wilson W, Woodward M, Zhang P

Journal: International Psychogeriatrics

Volume & Issue: 26 & 4

Page No.: 543-54

DOI: 10.1017/S1041610213001956

Year Published: 2014

BACKGROUND: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship Study of Ageing is a prospective study of 1,112 individuals (211 with Alzheimer’s disease (AD), 133 with mild cognitive impairment (MCI), and 768 healthy controls (HCs)). Here we report diagnostic and cognitive findings at the first (18-month) follow-up of the cohort. The first aim was to […]