Performances on the CogState and standard neuropsychological batteries among HIV patients without dementia

October 30, 2014

Authors: Edgar Turner Overton, John S K Kauwe, Robert Paul, Karen Tashima, David F Tate, Pragna Patel, Charles C J Carpenter, David Patty, John T Brooks, David B Clifford

Journal: AIDS and Behavior

DOI: 10.1007/s10461-011-0033-9

Year Published: 2011

HIV-associated neurocognitive disorders remain prevalent but challenging to diagnose particularly among non-demented individuals. To determine whether a brief computerized battery correlates with formal neurocognitive testing, we identified 46 HIV-infected persons who had undergone both formal neurocognitive testing and a brief computerized battery. Simple detection tests correlated best with formal neuropsychological testing. By multivariable regression model, 53% of the variance in the composite Global Deficit Score was accounted for by elements from the brief computerized tool (P < 0.01). These data confirm previous correlation data with the computerized battery. Using the five significant parameters from the regression model in a Receiver Operating Characteristic curve, 90% of persons were accurately classified as being cognitively impaired or not. The test battery requires additional evaluation, specifically for identifying persons with mild impairment, a state upon which interventions may be effective.

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