Cogstate Schizophrenia Battery (CSB)
Cogstate’s computerized battery of rapid, reliable, simple, and sensitive tests measure the cognitive domains affected by schizophrenia and identified by the National Institute of Mental Health (NIMH) Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) project. These are: Speed of processing (Detection), Verbal learning (International shopping list), Working memory (One-back), Reasoning and problem solving (Groton maze), Visual learning (One-card learning), Social cognition (Social emotional cognition), Attention vigilance (Identification).
The key outcome measures from each test are combined to form a single total ‘global cognition’ score using an average of the standardized z-scores. The CSB global cognition score is intended to be used as a co-primary outcome measure of efficacy in clinical trials of new drug treatments for Cognitive Impairment Associated with Schizophrenia (CIAS).
Each Cogstate cognitive test has comparative/normative data available for both clinical samples and healthy controls. Tests maintain excellent reliability across repeated testing and cross-sectional research designs. The battery that Cogstate recommends for schizophrenia trials aligns to the domains identified by the MATRICS project.
Final battery recommendations may vary based on study needs.
| Cogstate Tests in a Schizophrenia Battery Can Include: | Detection Test Identification Test One Card Learning Test One Back Test Two Back Test International Shopping List Test Groton Maze Learning Test Social-Emotional Cognition Test Continuous Paired Associate Learning Test |
| Length: | Approx. 40 minutes (depending on tests selected) |
| Administration: | Standardized |
| Data Processing and Scoring: | Automated |
| Application: | Phase I-IV |
| Culture and Language Neutral: | Yes |
