Multiple Sclerosis

Improving Cognitive Assessment with Higher Fidelity Measures

Cognitive impairment affects 50-70% of Multiple Sclerosis (MS) patients and is noted as one of the most disabling aspects of the disease. Worsening cognitive processing speed impacts patients’ quality of life as simple tasks become more difficult.

Addressing cognitive impairment and decline is vital in the development of MS treatments. Cogstate supports sponsors in these efforts by providing highly sensitive and reliable computerized cognitive testing, as well as support for conventional assessments, such as the BICAMS, MSFC, and PASAT.

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Optimize Clinical Outcome Assessment in Multiple Sclerosis Clinical Trials

Cogstate’s team of scientific and operational experts deliver innovative technology, proven operational delivery models, and leading scientific support for both digital and conventional clinical outcome assessments in MS trials.

Guidance to Select Validated, Fit-For-Purpose Tools to Collect Outcomes Relevant to Cognitive Impairment in MS

Choosing appropriate endpoints and designing strategic protocols are important decisions in the planning phase that impact future study results. Cogstate’s team of scientists have the expertise to advise your team on vital study considerations, help you answer key drug development questions, and design trials with reduced risk and uncertainty.

Leverage Sensitive and Reliable Computerized Cognitive Batteries

Cogstate’s computerized batteries of highly sensitive tests provide rapid and reliable measurement of distinct cognitive domains affected by MS such as processing speed and attention. Tests can be grouped into customizable batteries for a complete and nuanced picture of a subject’s cognitive state. Cogstate tests are culture- and education-neutral and designed for repeated administration with minimal practice or learning effects, making them ideal for use in global clinical trials. Tests have high patient acceptability and reduce burden on patient and sites.

Implement Robust Data Quality Programs for Conventional Assessments

Subjective assessments create the potential for variability in administration and scoring that may compromise the integrity of a clinical trial. Cogstate supports all aspects of data quality programs for MS cognitive and motor assessments—rater training and certification, subject eligibility review, central monitoring—with proven methodologies and leading technologies that drive endpoint reliability. Studies also benefit from our global network of Local Expert Advisors (LEADs) who are highly trained clinical and scientific experts that provide assessment support in 40+ languages.

Support Electronic Deployment of All Assessments via eCOA Systems

Cogstate partners with industry leading eCOA providers to deliver enhanced tablet-based scales and web-based eSource solutions, combining a user-friendly interface with a secure and reliable data management platform. Custom edit checks and automated scoring help prevent errors, and same day access to cleaner source data enables risk-based central monitoring by our clinical experts for greater quality assurance.

Wearable Sensors for a Complete Picture of Patient Functioning

Cogstate’s strategic partners at ERT deliver a complete wearable precision motion sensor solution that provides meaningful and functional insights for sponsors and patients through the capture of digital biomarkers. When integrated with Cogstate’s clinical outcome assessments of cognition or ERT’s data capture solutions for cardiac safety, eCOA, digital patient, imaging, or respiratory, digital biomarkers provide a holistic story of how a disease and therapy impacts patient function.

The Cogstate Multiple Sclerosis Battery

Cogstate’s computerized battery of rapid, reliable, simple, and sensitive tests measure the cognitive domains affected by MS: processing speed, attention, verbal and visual learning, working memory, visual motor function, and executive function.

Each cognitive test has been shown to be valid for use in different cultures and language groups with comparative/normative data available for both clinical samples and healthy controls. Tests have been used in all phases of drug trials and maintain excellent reliability across repeated testing and cross-sectional research designs.

The battery takes between 5-40 minutes (depending on the tests included), has standardized administration, and automated data processing and scoring.

Cognitive tests in the MS battery can include:

  • Detection Test [Psychomotor Function]
  • Identification Test [Attention]
  • One Card Learning Test [Visual Learning]
  • One Back Test [Working Memory]
  • Two Back Test [Working Memory]
  • International Shopping List Test [Verbal Learning]
  • Groton Maze Learning Test [Executive Function]

WATCH DEMOS OF OUR COMPUTERIZED TESTS

Decentralized Clinical Trials

We help bring the trial to the patient

As more clinical trials realize the potential of decentralization, Cogstate digital endpoints are enabling at-home, self-administered assessment and our remote rating services are enabling at-home clinician-administered assessment to drive both enhanced data quality as well as patient enrollment, engagement and retention.

SEE HOW WE CAN SUPPORT YOUR FULLY REMOTE OR HYBRID TRIAL DELIVERY

Multiple Sclerosis Resources

[Webinar]

Digital Technologies for Assessing Patient Functioning in Multiple Sclerosis Clinical Trials

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[Blog]

Reliable and Valid Cognitive Test Results Obtained from MS Patients Performing Self-Administered Computerized Assessment

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[Brochure]

Multiple Sclerosis Clinical Trial Solutions from Cogstate

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Solutions for Every Stage of Your Study Development

Cogstate’s clinical trial services, coupled with innovative operational approaches, advanced analytics, and scientific consulting, help research teams draw conclusions from study data faster and with more accuracy. Learn how we can support your study:

Scientific Consulting

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Computerized Cognitive Assessment

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Rater Training

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Central Monitoring

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Scale Management

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Remote / At-home Testing

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