Cognigram Tests

A rapid and reliable cognitive screening assessment across indications and phases of development.

The Cogstate Brief Battery™ has been used extensively as a rapid and reliable screening assessment in a range of clinical indications, including Alzheimer’s Disease, depression, schizophrenia, AIDS, dementia complex and as a measure of cognitive decline following a mild traumatic brain injury or suspected concussive episode. The Cogstate Brief Battery has also been used widely in the context of measuring cognitive dysfunction relative to healthy groups in both pediatric and adult populations.

The Cogstate Brief Battery provides a measure of four core cognitive domains: processing speed, attention, visual learning and working memory. Study teams wishing to measure all or a subset of these domains can choose the tests that best suit their specific research questions. Each of the tests have been utilized previously in clinical trials and maintain excellent reliability across repeated testing and cross-sectional research designs. This battery maintains excellent psychometric properties in relation to test-retest reliability. The criterion and construct validity of each test for cognitive impairment as well as the sensitivity of these tests to change in cognition has been demonstrated in the scientific literature, and each test has also been shown to be valid for use in different cultures and language groups.

Computerized Tests

Detection Test

Cognitive Domain: Psychomotor Function

Administration Time: 3 Minutes (for healthy participants)

Outcome Measures: Speed of performance (mean of the log10 transformed reaction times for correct responses).

Test Description

The Detection test measures processing speed using a simple reaction time paradigm. The on-screen instructions ask: “Has the card turned over?”. A playing card is presented face down in the center of the screen. The card flips over so it is face up. As soon as the card flips over the participant must press “Yes”. The participant is encouraged to work as quickly as they can and be as accurate as possible.

Identification Test

Cognitive Domain: Attention

Administration Time: 3 Minutes (for healthy participants)

Outcome Measures: Speed of performance (mean of the log10 transformed reaction times for correct responses).

Test description

The Identification test measures attention using a choice reaction time paradigm. The on-screen instructions ask: “Is the card red?”. A playing card is presented face down in the center of the screen. The card flips over so it is face up. As soon as it flips over the participant must decide whether the card is red or not. If it is red the participant should press “Yes”, and if it is not red the participant should press “No”. The participant is encouraged to work as quickly as they can and be as accurate as possible.

One Card Learning Test

Cognitive Domain: Visual Learning

Administration Time: 6 Minutes (for healthy participants)

Outcome Measures: Accuracy of performance (arcsine transformation of the square root of the proportion of correct responses).

Test Description

The One Card Learning test measures visual memory using a pattern separation paradigm. The on-screen instructions ask: “Have you seen this card before in this test?”. A playing card is presented face up in the center of the screen and the participant must decide whether they have seen the card before in this test. The participant is encouraged to work as quickly as they can and be as accurate as possible.

One Back Test

Cognitive Domain: Working Memory

Administration Time: 4 Minutes (for healthy participants)

Outcome Measures: Speed of performance (mean of the log10 transformed reaction times for correct responses); Accuracy of performance (arcsine transformation of the square root of the proportion of correct responses).

Test Description

The One Back test measures working memory using an n-back paradigm. The on-screen instructions ask: “Is the previous card the same?”. A playing card is presented face up in the center of the screen. The participant must decide whether the card is the same as the previous card. If the card is the same the participant should press “Yes”, and if it is not the same the participant should press “No”. The participant is encouraged to work as quickly as they can and be as accurate as possible.

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