Research

The latest from Cogstate, leaders in optimizing the measurement of cognition

New Study Of HIV−Associated Neurocognitive Disorders (HAND) Uses An Innovative Approach To Functional Assessments For Activities Of Daily Living And Correlates To Cogstate Test Performance 

November 23, 2017

Navigating the Internet to get daily shopping and banking tasks done has become a necessary skill for just about all of us. Searching for products, comparing pricing, entering credit card and shipping information across multiple websites can sometimes be challenging even for experienced users. But for those persons who also struggle with cognitive dysfunction from […]

New Study Shows Prolonged Site Exposure Among World Trade Center First Responders Is Associated with Cognitive Dysfunction

November 17, 2017

More than sixteen years after the horrific terrorist attacks at the World Trade Center (WTC) in New York City on September 11, 2001, there is still a large segment of the first responders that suffers from cognitive dysfunction as a result of their rescue and recovery efforts. Two leading explanations include the exposure to contaminated […]

Study Evaluates Computer-Based Cognitive Tests to Detect Impairment in Cirrhosis Patients with Hepatic Encephalopathy (HE)

October 11, 2017

Hepatic encephalopathy (HE) is one of the most challenging consequences of cirrhosis, a type of chronic liver disease, as it causes significant cognitive dysfunction in patients. Diagnosing HE has traditionally been done through a psychometric testing battery involving paper and pencil tests designed to assess motor speed, visual perception, visual-spatial orientation, concentration, attention and memory. […]

Pilot Study Demonstrates Working Memory Training May Be Effective For Children With Neurofibromatosis

June 27, 2017

While neurofibromatosis often appears in children as visible spots, freckles or tiny bumps, the genetic disorder can also cause learning disabilities, including problems with attention, working memory, inhibition and planning. Up to 40% of children with neurofibromatosis type 1 (NF1) are diagnosed with Attention Deficit/Hyperactivity Disorder (ADHD). These symptoms can often cause issues at home […]

Cogstate Brief Battery Shows Correlation With Traditional Tests of Cognition In Breast Cancer Population

May 1, 2017

As the complexity and geographic distribution of clinical trials increase, there is a growing need for more efficient cognitive testing of participants. Traditional “pencil and paper” neuropsychological tests have been the gold standard but require expert administration and manual data collection. To scale to hundreds of patients located around the world, computerized cognitive testing offers […]

AMPAR Potentiators May Have Role In The Treatment Of The Cognitive Symptoms Associated With Schizophrenia

March 15, 2017

Treating schizophrenia involves not only addressing the primary positive and negative symptoms but also the frequent cognitive dysfunction that accompanies the disorder, known as cognitive impairment associated with schizophrenia (CIAS). These deficits in attention, working memory and executive function have a detrimental impact on a patient’s quality of life and their functional capacity to manage […]

Cognitive Decline and PTSD Symptoms Linked In Large Study Of Civilian Women

January 20, 2017

Living through a traumatic event is an unfortunate reality for many people with each episode resulting in varying recovery timelines and potentially long-term effects. When lasting effects result in daily challenges to normal activities, a diagnosis of post-traumatic stress disorder (PTSD) can trigger a treatment protocol of medications, counseling and support to help manage ongoing […]

High Blood Pressure In Children Negatively Impacts Cognitive Performance

November 16, 2016

According to the Centers for Disease Control and Prevention, obesity among U.S. children and adolescents (aged 2-19) remained high between 2011 and 2014 at about 17%. Of these approximately 13 million young people, almost 10% are also diagnosed with primary hypertension, risking long-term cardiovascular organ damage as they move into adulthood. Beyond its physical effects, […]

Study Finds Brexpiprazole To Be An Effective Alternative To Aripiprazole

November 8, 2016

Despite the number of available antipsychotics, schizophrenia is still a complicated brain disorder to treat, in part due to the different side effects of various treatment regimens between patients. Brexpiprazole, a serotonin-dopamine activity modulator approved by the FDA for schizophrenia in 2015, was developed by Otsuka as a successor to aripiprazole, whose U.S. patent expired […]

Cogstate Computerized Battery Effective For Long-Term Monitoring of Cognitive Side Effects in Pediatric Leukemia Patients

October 20, 2016

Children with acute lymphoblastic leukemia (ALL) often battle neurocognitive deficits as a result of their radiation or chemotherapy treatment. During treatment and sometimes up to two years after treatment, their quality of life is affected by impairments in attention, processing speed and executive functioning. While many pediatric leukemia studies have identified possible counter measures later […]

Study Highlights Correlation Between Cogstate Battery And Traditional Neuropsychological Tests

October 12, 2016

Detecting the earliest signs of cognitive decline in older adults provides clinicians and researchers with opportunities to study the beginning stages of dementia, particularly Alzheimer’s disease (AD). Some traditional “paper and pencil” neuropsychological tests provide accuracy and a rich database of historical studies, but they can also present challenges such as ensuring standardized administration, cultural […]

Study Confirms Biomarkers Combined With Sensitive Cognitive Tests Are Important For Identifying Early Stage Alzheimer’s Disease

September 24, 2016

After more than ten years, the amyloid cascade hypothesis of Alzheimer’s disease (AD) is still at the core of new research findings. By proposing that AD starts with the accumulation of beta amyloid (Aβ) protein plaques in the brain, which may lead to the twisted tangles of the tau protein, researchers have focused on the […]

Subjective Memory Decline Shown To Be Early Warning Sign Of Cognitive Disease

September 9, 2016

The first signs of cognitive decline among older adults are often memory-related. Forgetting a name, misplacing objects, or not remembering prior conversations becomes more common over the age of 50, sometimes leading to concerns that this forgetfulness is more than just normal aging. Known as subjective memory decline (SMD), researchers are asking if these episodes […]

Research Finds Neurodegeneration In The Absence Of Beta Amyloid Is Not Associated With Cognitive Decline

August 30, 2016

As we age, our brains inevitably change just as the rest of our bodies do. Once past 60 years old, some of those changes can become noticeable in our daily lives such as small slips of memory. With the increasing information available on Alzheimer’s disease, dementia and other age-related cognitive decline, those signs can cause […]

Computerised Cognitive Test Battery Matches Gold Standard for HAND Screening

July 8, 2016

Besides enduring the challenges of HIV infection, 20-50% of patients also experience cognitive decline, including difficulty with attention, memory and executive functions. Diagnosed as HIV-associated neurocognitive disorder (HAND), the symptoms can cause difficulty with everyday work/life tasks and may progress to more severe limitations over time. Standard neuropsychological (NP) tests can identify the three categories […]

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