Alzheimer’s disease

The latest from Cogstate, leaders in optimizing the measurement of cognition

Study Highlights Correlation Between Cogstate Battery And Traditional Neuropsychological Tests

October 12, 2016

Detecting the earliest signs of cognitive decline in older adults provides clinicians and researchers with opportunities to study the beginning stages of dementia, particularly Alzheimer’s disease (AD). Some traditional “paper and pencil” neuropsychological tests provide accuracy and a rich database of historical studies, but they can also present challenges such as ensuring standardized administration, cultural […]

Study Confirms Biomarkers Combined With Sensitive Cognitive Tests Are Important For Identifying Early Stage Alzheimer’s Disease

September 24, 2016

After more than ten years, the amyloid cascade hypothesis of Alzheimer’s disease (AD) is still at the core of new research findings. By proposing that AD starts with the accumulation of beta amyloid (Aβ) protein plaques in the brain, which may lead to the twisted tangles of the tau protein, researchers have focused on the […]

Subjective Memory Decline Shown To Be Early Warning Sign Of Cognitive Disease

September 9, 2016

The first signs of cognitive decline among older adults are often memory-related. Forgetting a name, misplacing objects, or not remembering prior conversations becomes more common over the age of 50, sometimes leading to concerns that this forgetfulness is more than just normal aging. Known as subjective memory decline (SMD), researchers are asking if these episodes […]

Research Finds Neurodegeneration In The Absence Of Beta Amyloid Is Not Associated With Cognitive Decline

August 30, 2016

As we age, our brains inevitably change just as the rest of our bodies do. Once past 60 years old, some of those changes can become noticeable in our daily lives such as small slips of memory. With the increasing information available on Alzheimer’s disease, dementia and other age-related cognitive decline, those signs can cause […]

Study Provides New Insight Into Relationship Of Beta Amyloid And APOE4 To Cognitive Decline

April 29, 2016

In the continuing search for the underlying causes of Alzheimer’s disease, two biomarkers consistently demonstrate their significance; the levels of beta amyloid (Aβ) in the brain and the presence of the Apolipoprotein E (APOE) ε4 allele genotype. Previous studies have shown that in cognitively normal older adults, the combination of high levels of Aβ with […]

Dementia With Lewy Bodies Predicted By Autonomic Testing in Major Depressive Disorder

April 1, 2016

As the third leading type of dementia, behind only Alzheimer’s disease and vascular dementia, dementia with Lewy bodies (DLB) is often linked with symptoms similar to Parkinson’s disease. Present in several other brain disorders, Lewy bodies are abnormal aggregates of protein, primarily alpha-synuclein. Detecting Lewy bodies early before dementia-related symptoms emerge is important to the […]

Study Finds Use of Nicotinic Alpha-7 Agonist Improves Cognitive Function In Parkinson’s Patients

March 24, 2016

For patients diagnosed with Parkinson’s disease (PD), the need to balance effective treatments with their unpleasant side effects is an ongoing battle. Long considered the gold standard for treating early symptoms of PD, levodopa (L-DOPA) is able to cross the blood-brain barrier to produce dopamine in the brain which helps manage the symptoms of motor […]

Heart Health And Cognitive Function Linked In New Study

February 23, 2016

While today’s medical research tends to divide the human body into separate systems to better focus on specific disease states, our overall health is still an integrated whole. Two of these systems, cardiovascular and the central nervous system, have been shown to influence each other. A heart suffering from cardiovascular disease can affect the available […]

Predicting Surgery-Related Cognitive Dysfunction Using An Alzheimer’s Disease Biomarker

February 9, 2016

With average lifespans increasing thanks to improved medical care and healthy habits, older adults are undergoing more major surgeries, whether it be for cardiac care or orthopaedic conditions. However, one of the side effects of operations requiring significant anesthesia is a form of cognitive decline immediately after recovery that may last for weeks or months. […]

Self-Administered Cogstate Computerized Cognitive Test Results Correlated with Known Risk Factors Associated with Cognitive Function

January 14, 2016

As the percentage of the global population over the age of 65 continues to rise, diagnoses of Alzheimer’s disease are also quickly growing. While 5.1 million Americans in this age group have already been diagnosed with Alzheimer’s disease, that number is predicted to grow by 40% by 2025, according to the Alzheimer’s Association. With the […]

Cognitive Decline Found In Adults With High Beta Amyloid And APOE ε4 Gene Over Just 18 Months

October 14, 2015

“So, even in this shortened 18-month trial, the combined effects of high beta amyloid with the APOE ε4 biomarker demonstrated neurodegneration.” As neuroscientists tease apart the contributing factors leading to cognitive decline, and eventually Alzheimer’s disease, in older adults, two biomarkers keep surfacing as probable causes; amyloid beta plaques (Aβ+) in the brain and carrying […]

New Study Links Rilapladib To Cognitive Improvement

September 13, 2015

“The finding that rilapladib improved cognition in this group is very exciting” In a much anticipated research update, GlaxoSmithKline (GSK) has released the results of a two-year study of rilapladib as a possible treatment for dementia. Using tests for executive function and working memory from Cogstate, GSK researchers were able to observe cognitive improvement in […]

A Cognitive Stress Test: Scopolamine And The Groton Maze Learning Test

August 26, 2015

Early identification of cognitively normal older adults who are in the preclinical stage of Alzheimer’s disease Researchers in the ongoing search for possible treatments of Alzheimer’s disease are starting to blend different hypotheses of its causes. One such theory, known as the cholinergic hypothesis, proposes that the production of the neurotransmitter acetylcholine becomes disrupted in […]

COGSTATE RELEASES LATEST VERSION OF ONLINE COGNITIVE SCREENING SOLUTION FOR CLINICAL TRIALS: PRECISION RECRUITMENT

July 28, 2015

ADDRESSING THE MOUNTING CHALLENGE OF PATIENT RECRUITMENT IN ALZHEIMER’S DISEASE CLINICAL TRIALS AND OTHER HIGH-NEED INDICATIONS Melbourne, Australia – 22 July 2015: Cogstate Ltd (ASX.CGS), a cognitive science and medical technology company, today announced the latest version of its remote cognitive assessment solution for pre-screening participants in clinical trials, Precision Recruitment™ 2.1. Precision Recruitment™ supports […]

Study Indicates Rate of Beta Amyloid Accumulation Associated With Rate of Decline in Memory

June 23, 2015

As researchers gain greater understanding of the many processes that give rise to the dementia Alzheimer’s disease, they begin to appreciate relationships and linkages between changes in brain chemistry and brain biology and how such changes manifest in behavior. Combining an understanding of the physiological changes with behavioral changes helps establish the order of causality […]

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